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. 2017 Mar 31;12(3):e0174810.
doi: 10.1371/journal.pone.0174810. eCollection 2017.

Comparison of laser in situ ketatomileusis and photorefractive keratectomy for myopia using a mixed-effects model

Yosai Mori  1 , Kazunori Miyata  1 , Takashi Ono  1 , Yusuke Yagi  1 , Kazutaka Kamiya  2 , Shiro Amano  3
Affiliations

Comparison of laser in situ ketatomileusis and photorefractive keratectomy for myopia using a mixed-effects model

Yosai Mori et al. PLoS One. .

Abstract

Purpose: To compare the results of laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) for myopia using a mixed-effects model.

Methods: This comparative retrospective study was conducted in 1,127 eyes of 579 patients after LASIK and 270 eyes of 144 patients after PRK who had two or more postoperative follow-ups after 3 months. Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), manifest refractive spherical equivalent (MRSE), percentage of eyes within ± 0.5 diopters (D) and ± 1.0 D of targeted refraction, and central corneal thickness were compared between PRK and LASIK groups using a mixed-effects model.

Results: Compared with the LASIK group, UCVA in the PRK group was significantly worse in the initial year but was significantly better after 4 years. The average BSCVA was not significantly different between the LASIK and PRK groups after 4 years. The average gain of BSCVA in the PRK group was significantly larger than that of the LASIK group after 2 years. MRSE in the LASIK and PRK groups showed a gradual myopic shift until 6 years after surgery. After 6 years, MRSE in the PRK group remained stable whereas MRSE in the LASIK group continued a myopic shift. The percentages of eyes within ± 0.5 D or ± 1.0 D in the LASIK group were significantly higher than those in the PRK group at 3 months but were significantly lower than those in the PRK group at 10 years.

Conclusions: PRK for myopia shows better efficacy than LASIK for myopia after 4 years.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Time courses of the average and 95% confidence intervals of uncorrected visual acuity in the laser in situ keratomileusis (closed square) and photorefractive keratectomy (open square) groups.
* p< .05.
Fig 2
Fig 2. Time courses of the average and 95% confidence intervals of best spectacle-corrected visual acuity in the laser in situ keratomileusis (closed square) and photorefractive keratectomy (open square) groups.
* p< .05.
Fig 3
Fig 3. Time courses of the average and 95% confidence intervals of change of best spectacle-corrected visual acuity in the laser in situ keratomileusis (closed square) and photorefractive keratectomy (open square) groups.
* p< .05.
Fig 4
Fig 4. Time courses of the average and 95% confidence intervals of manifest refractive spherical equivalent in the laser in situ keratomileusis (closed square) and photorefractive keratectomy (open square) groups.
* p< .05.
Fig 5
Fig 5. Time courses of the average and 95% confidence intervals of change of central corneal thickness from 3 months in the laser in situ keratomileusis (closed square) and photorefractive keratectomy (open square) groups.
* p< .05.
See this image and copyright information in PMC

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