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. 2017 Mar 31;12(3):e0175035.
doi: 10.1371/journal.pone.0175035. eCollection 2017.

The genetic evolution of canine parvovirus - A new perspective

Pei Zhou  1   2   3 , Weijie Zeng  1   2   3 , Xin Zhang  1   2   3 , Shoujun Li  1   2   3
Affiliations

The genetic evolution of canine parvovirus - A new perspective

Pei Zhou et al. PLoS One. .

Abstract

To trace the evolution process of CPV-2, all of the VP2 gene sequences of CPV-2 and FPV (from 1978 to 2015) from GenBank were analyzed in this study. Then, several new ideas regarding CPV-2 evolution were presented. First, the VP2 amino acid 555 and 375 positions of CPV-2 were first ruled out as a universal mutation site in CPV-2a and amino acid 101 position of FPV feature I or T instead of only I in existing rule. Second, the recently confusing nomenclature of CPV-2 variants was substituted with a optional nomenclature that would serve future CPV-2 research. Third, After check the global distribution of variants, CPV-2a is the predominant variant in Asia and CPV-2c is the predominant variant in Europe and Latin America. Fourth, a series of CPV-2-like strains were identified and deduced to evolve from modified live vaccine strains. Finally, three single VP2 mutation (F267Y, Y324I, and T440A) strains were caught concern. Furthermore, these three new VP2 mutation strains may be responsible for vaccine failure, and the strains with VP2 440A may become the novel CPV sub-variant. In conclusion, a summary of all VP2 sequences provides a new perspective regarding CPV-2 evolution and the correlative biological studies needs to be further performed.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The aa percentages and numbers at the VP2 297 site.
Fig 2
Fig 2. The percentages and numbers of original CPV-2/CPV-2-like, CPV-2a, CPV-2b, and CPV-2c.
Fig 3
Fig 3. The global distribution of CPV-2a\2b\2c.
Fig 4
Fig 4. The aa percentages and numbers at the VP2 267 site.
Fig 5
Fig 5. The aa percentages and numbers at the VP2 324 site.
Fig 6
Fig 6. The aa percentages and numbers at the VP2 440 site.
Fig 7
Fig 7. A structure model of VP2 and the distribution of the new aa mutation sites (267, 324, 440).
These locations were visualized using the PyMOL Molecular Graphics System, version 1.5.0.4 Schrödinger, LLC.
See this image and copyright information in PMC

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