Multicenter Study

. 2017 Aug:187:141-146.e1.

doi: 10.1016/j.jpeds.2017.03.007. Epub 2017 Mar 30.

Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

Collaborators, Affiliations

Collaborators

Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN):
Stephanie H Abrams¹¹, Sarah Barlow¹¹, Ryan Himes¹¹, Rajesh Krisnamurthy¹¹, Leanel Maldonado¹¹, Rory Mahabir¹¹, April Carr¹², Kimberlee Bernstein¹², Kristin Bramlage¹², Kim Cecil¹², Stephanie DeVore¹², Rohit Kohli¹², Kathleen Lake¹², Daniel Podberesky¹², Alex Towbin¹², Stavra Xanthakos¹², Daniela Allende¹³, Srinivasan Dasarathy¹³, Arthur J McCullough¹³, Mangesh Pagadala¹³, Rish Pai¹³, Cha'Ron Winston¹³, Gerald Behr¹⁴, Joel E Lavine¹⁴, Jay H Lefkowitch¹⁴, Ali Mencin¹⁴, Elena Reynoso¹⁴, Manal F Abdelmalek¹⁵, Mustafa Bashir¹⁵, Stephanie Buie¹⁵, Anna Mae Diehl¹⁵, Cynthia Guy¹⁵, Christopher Kigongo¹⁵, David Malik¹⁵, Yi-Ping Pan¹⁵, Dawn Piercy¹⁵, Mariko Kopping¹⁵, Tyler Thrasher¹⁵, Adina Alazraki¹⁶, Rebecca Cleeton¹⁶, Maria Cordero¹⁶, Albert Hernandez¹⁶, Saul Karpen¹⁶, Jessica Cruz Munos¹⁶, Nicholas Raviele¹⁶, Miriam Vos¹⁶, Molly Bozic¹⁷, Naga Chalasani¹⁷, Oscar W Cummings¹⁷, Samer Gawrieh¹⁷, Ann Klipsch¹⁷, Jean P Molleston¹⁷, Emily Ragozzino¹⁷, Linda Ragozzino¹⁷, Kumar Sandrasegaran¹⁷, Girish Subbarao¹⁷, Raj Vuppalanchi¹⁷, Laura Walker¹⁷, Kimberly Kafka¹⁸, Ann Scheimann¹⁸, Joy Ito¹⁹, Mark H Fishbein¹⁹, Saeed Mohammad¹⁹, Cynthia Rigsby¹⁹, Lisa Sharda¹⁹, Peter F Whitington¹⁹, Sarah Barlow²⁰, Theresa Cattoor²⁰, Jose Derdoy²⁰, Janet Freebersyser²⁰, Ajay Jain²⁰, Debra King²⁰, Jinping Lai²⁰, Pat Osmack²⁰, Joan Siegner²⁰, Susan Stewart²⁰, Brent A Neuschwander-Tetri²⁰, Susan Torretta²⁰, Kristina Wriston²⁰, Fereshteh Assadian²¹, Vanessa Barone²¹, Maria Cardona Gonzalez²¹, Jodie Davila²¹, Oren Fix²¹, Kelly Anne Hennessey²¹, Kris V Kowdley²¹, Kacie Lopez²¹, Erik Ness²¹, Michelle Poitevin²¹, Nicholas Procaccini²¹, Brook Quist²¹, Alana Saddic²¹, Cara Wiseman²¹, Matthew Yeh²¹, Susan S Baker²², Diana Lopez-Graham²², Sonja Williams²², Lixin Zhu²², Jonathan Africa²³, Brandon Ang²³, Hannah Awai²³, Cynthia Behling²³, Archana Bhatt²³, Craig Bross²³, Jennifer Collins²³, Janis Durelle²³, Kathryn Harlow²³, Rohit Loomba²³, Michael Middleton²³, Kimberly Newton²³, Melissa Paiz²³, Jeffrey B Schwimmer²³, Claude Sirlin²³, Patricia Ugalde-Nicalo²³, Mariana Dominguez Villarreal²³, Bradley Aouizerat²⁴, Nathan M Bass²⁴, Danielle Brandman²⁴, Jesse Courtier²⁴, Linda D Ferrell²⁴, Natasha Feier²⁴, Ryan Gill²⁴, Bilal Hameed²⁴, Camille Langlois²⁴, Jacqueline Maher²⁴, Emily Rothbaum Perito²⁴, Claudia Ramos²⁴, Philip Rosenthal²⁴, Norah Terrault²⁴, Patrika Tsai²⁴, Ashley Ungermann²⁴, Pradeep Atla²⁵, Brandon Croft²⁵, Rebekah Garcia²⁵, Sonia Garcia²⁵, Muhammad Sheikh²⁵, Mandeep Singh²⁵, Kara Cooper²⁶, Simon Horslen²⁶, Evelyn Hsu²⁶, Karen Murray²⁶, Randolph Otto²⁶, Matthew Yeh²⁶, Melissa Young²⁶, Sherry Boyett²⁷, Laura Carucci²⁷, Melissa J Contos²⁷, Sherri Kirwin²⁷, Kenneth Kraft²⁷, Velimir A C Luketic²⁷, Puneet Puri²⁷, Arun J Sanyal²⁷, Jolene Schlosser²⁷, Mohammad S Siddiqui²⁷, Elizabeth M Brunt²⁸, Kathryn Fowler²⁸, David E Kleiner²⁹, Sherry Brown³⁰, Edward C Doo³⁰, Jay H Hoofnagle³⁰, Patricia R Robuck³⁰, Averell Sherker³⁰, Rebecca Torrance³⁰, Patricia Belt³¹, Jeanne M Clark³¹, Michele Donithan³¹, Erin Hallinan³¹, Milana Isaacson³¹, Kevin P May³¹, Laura Miriel³¹, Alice Sternberg³¹, James Tonascia³¹, Mark Van Natta³¹, Laura Wilson³¹, Katherine Yates³¹

Affiliations

¹ Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA; Division of Gastroenterology, Department of Pediatrics, Rady Children's Hospital, San Diego, CA.
² Division of Dysmorphology and Teratology, Department of Pediatrics, University of California San Diego, La Jolla, CA.
³ Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD; Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD.
⁴ Department of Pathology, Sharp Medical Center, San Diego, CA.
⁵ Department of Pediatrics, Riley Children's Hospital, Indianapolis, IN.
⁶ Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
⁷ Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA.
⁸ Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.
⁹ Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University, New York, NY.
¹⁰ Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA; Division of Gastroenterology, Department of Pediatrics, Rady Children's Hospital, San Diego, CA. Electronic address: jschwimmer@ucsd.edu.
¹¹ Baylor College of Medicine, Houston, TX.
¹² Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
¹³ Cleveland Clinic Foundation, Cleveland, OH.
¹⁴ Columbia University, New York, NY.
¹⁵ Duke University Medical Center, Durham, NC.
¹⁶ Emory University, Atlanta, GA.
¹⁷ Indiana University School of Medicine, Indianapolis, IN.
¹⁸ Johns Hopkins Hospital, Baltimore, MD.
¹⁹ Northwestern University Feinberg School of Medicine/Ann & Robert H. Lurie Children's Hospital of Chicago.
²⁰ Saint Louis University, St Louis, MO.
²¹ Swedish Medical Center, Seattle, WA.
²² University at Buffalo, Buffalo, NY.
²³ University of California San Diego, San Diego, CA.
²⁴ University of California San Francisco, San Francisco, CA.
²⁵ University of California San Francisco- Fresno, Fresno, CA.
²⁶ University of Washington Medical Center and Seattle Children's Hospital, Seattle, WA.
²⁷ Virginia Commonwealth University, Richmond, VA.
²⁸ Washington University, St. Louis, MO.
²⁹ National Cancer Institute, Bethesda, MD.
³⁰ National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
³¹ Johns Hopkins University, Bloomberg School of Public Health (Data Coordinating Center), Baltimore, MD.

PMID: 28366357
PMCID: PMC5533631
DOI: 10.1016/j.jpeds.2017.03.007

Multicenter Study

Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

Kimberly P Newton et al. J Pediatr. 2017 Aug.

. 2017 Aug:187:141-146.e1.

doi: 10.1016/j.jpeds.2017.03.007. Epub 2017 Mar 30.

Collaborators

Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN):
Stephanie H Abrams¹¹, Sarah Barlow¹¹, Ryan Himes¹¹, Rajesh Krisnamurthy¹¹, Leanel Maldonado¹¹, Rory Mahabir¹¹, April Carr¹², Kimberlee Bernstein¹², Kristin Bramlage¹², Kim Cecil¹², Stephanie DeVore¹², Rohit Kohli¹², Kathleen Lake¹², Daniel Podberesky¹², Alex Towbin¹², Stavra Xanthakos¹², Daniela Allende¹³, Srinivasan Dasarathy¹³, Arthur J McCullough¹³, Mangesh Pagadala¹³, Rish Pai¹³, Cha'Ron Winston¹³, Gerald Behr¹⁴, Joel E Lavine¹⁴, Jay H Lefkowitch¹⁴, Ali Mencin¹⁴, Elena Reynoso¹⁴, Manal F Abdelmalek¹⁵, Mustafa Bashir¹⁵, Stephanie Buie¹⁵, Anna Mae Diehl¹⁵, Cynthia Guy¹⁵, Christopher Kigongo¹⁵, David Malik¹⁵, Yi-Ping Pan¹⁵, Dawn Piercy¹⁵, Mariko Kopping¹⁵, Tyler Thrasher¹⁵, Adina Alazraki¹⁶, Rebecca Cleeton¹⁶, Maria Cordero¹⁶, Albert Hernandez¹⁶, Saul Karpen¹⁶, Jessica Cruz Munos¹⁶, Nicholas Raviele¹⁶, Miriam Vos¹⁶, Molly Bozic¹⁷, Naga Chalasani¹⁷, Oscar W Cummings¹⁷, Samer Gawrieh¹⁷, Ann Klipsch¹⁷, Jean P Molleston¹⁷, Emily Ragozzino¹⁷, Linda Ragozzino¹⁷, Kumar Sandrasegaran¹⁷, Girish Subbarao¹⁷, Raj Vuppalanchi¹⁷, Laura Walker¹⁷, Kimberly Kafka¹⁸, Ann Scheimann¹⁸, Joy Ito¹⁹, Mark H Fishbein¹⁹, Saeed Mohammad¹⁹, Cynthia Rigsby¹⁹, Lisa Sharda¹⁹, Peter F Whitington¹⁹, Sarah Barlow²⁰, Theresa Cattoor²⁰, Jose Derdoy²⁰, Janet Freebersyser²⁰, Ajay Jain²⁰, Debra King²⁰, Jinping Lai²⁰, Pat Osmack²⁰, Joan Siegner²⁰, Susan Stewart²⁰, Brent A Neuschwander-Tetri²⁰, Susan Torretta²⁰, Kristina Wriston²⁰, Fereshteh Assadian²¹, Vanessa Barone²¹, Maria Cardona Gonzalez²¹, Jodie Davila²¹, Oren Fix²¹, Kelly Anne Hennessey²¹, Kris V Kowdley²¹, Kacie Lopez²¹, Erik Ness²¹, Michelle Poitevin²¹, Nicholas Procaccini²¹, Brook Quist²¹, Alana Saddic²¹, Cara Wiseman²¹, Matthew Yeh²¹, Susan S Baker²², Diana Lopez-Graham²², Sonja Williams²², Lixin Zhu²², Jonathan Africa²³, Brandon Ang²³, Hannah Awai²³, Cynthia Behling²³, Archana Bhatt²³, Craig Bross²³, Jennifer Collins²³, Janis Durelle²³, Kathryn Harlow²³, Rohit Loomba²³, Michael Middleton²³, Kimberly Newton²³, Melissa Paiz²³, Jeffrey B Schwimmer²³, Claude Sirlin²³, Patricia Ugalde-Nicalo²³, Mariana Dominguez Villarreal²³, Bradley Aouizerat²⁴, Nathan M Bass²⁴, Danielle Brandman²⁴, Jesse Courtier²⁴, Linda D Ferrell²⁴, Natasha Feier²⁴, Ryan Gill²⁴, Bilal Hameed²⁴, Camille Langlois²⁴, Jacqueline Maher²⁴, Emily Rothbaum Perito²⁴, Claudia Ramos²⁴, Philip Rosenthal²⁴, Norah Terrault²⁴, Patrika Tsai²⁴, Ashley Ungermann²⁴, Pradeep Atla²⁵, Brandon Croft²⁵, Rebekah Garcia²⁵, Sonia Garcia²⁵, Muhammad Sheikh²⁵, Mandeep Singh²⁵, Kara Cooper²⁶, Simon Horslen²⁶, Evelyn Hsu²⁶, Karen Murray²⁶, Randolph Otto²⁶, Matthew Yeh²⁶, Melissa Young²⁶, Sherry Boyett²⁷, Laura Carucci²⁷, Melissa J Contos²⁷, Sherri Kirwin²⁷, Kenneth Kraft²⁷, Velimir A C Luketic²⁷, Puneet Puri²⁷, Arun J Sanyal²⁷, Jolene Schlosser²⁷, Mohammad S Siddiqui²⁷, Elizabeth M Brunt²⁸, Kathryn Fowler²⁸, David E Kleiner²⁹, Sherry Brown³⁰, Edward C Doo³⁰, Jay H Hoofnagle³⁰, Patricia R Robuck³⁰, Averell Sherker³⁰, Rebecca Torrance³⁰, Patricia Belt³¹, Jeanne M Clark³¹, Michele Donithan³¹, Erin Hallinan³¹, Milana Isaacson³¹, Kevin P May³¹, Laura Miriel³¹, Alice Sternberg³¹, James Tonascia³¹, Mark Van Natta³¹, Laura Wilson³¹, Katherine Yates³¹

Affiliations

¹ Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA; Division of Gastroenterology, Department of Pediatrics, Rady Children's Hospital, San Diego, CA.
² Division of Dysmorphology and Teratology, Department of Pediatrics, University of California San Diego, La Jolla, CA.
³ Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD; Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD.
⁴ Department of Pathology, Sharp Medical Center, San Diego, CA.
⁵ Department of Pediatrics, Riley Children's Hospital, Indianapolis, IN.
⁶ Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
⁷ Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA.
⁸ Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.
⁹ Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University, New York, NY.
¹⁰ Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA; Division of Gastroenterology, Department of Pediatrics, Rady Children's Hospital, San Diego, CA. Electronic address: jschwimmer@ucsd.edu.
¹¹ Baylor College of Medicine, Houston, TX.
¹² Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
¹³ Cleveland Clinic Foundation, Cleveland, OH.
¹⁴ Columbia University, New York, NY.
¹⁵ Duke University Medical Center, Durham, NC.
¹⁶ Emory University, Atlanta, GA.
¹⁷ Indiana University School of Medicine, Indianapolis, IN.
¹⁸ Johns Hopkins Hospital, Baltimore, MD.
¹⁹ Northwestern University Feinberg School of Medicine/Ann & Robert H. Lurie Children's Hospital of Chicago.
²⁰ Saint Louis University, St Louis, MO.
²¹ Swedish Medical Center, Seattle, WA.
²² University at Buffalo, Buffalo, NY.
²³ University of California San Diego, San Diego, CA.
²⁴ University of California San Francisco, San Francisco, CA.
²⁵ University of California San Francisco- Fresno, Fresno, CA.
²⁶ University of Washington Medical Center and Seattle Children's Hospital, Seattle, WA.
²⁷ Virginia Commonwealth University, Richmond, VA.
²⁸ Washington University, St. Louis, MO.
²⁹ National Cancer Institute, Bethesda, MD.
³⁰ National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
³¹ Johns Hopkins University, Bloomberg School of Public Health (Data Coordinating Center), Baltimore, MD.

PMID: 28366357
PMCID: PMC5533631
DOI: 10.1016/j.jpeds.2017.03.007

Abstract

Objectives: To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD.

Study design: A multicenter, cross-sectional study of children with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network Database. Birth weight was categorized as low birth weight (LBW), normal birth weight (NBW), or high birth weight (HBW) and compared with the birth weight distribution in the general US population. The severity of liver histology was assessed by birth weight category.

Results: Children with NAFLD (n = 538) had overrepresentation of both LBW and HBW compared with the general US population (LBW, 9.3%; NBW, 75.8%; HBW, 14.9% vs LBW, 6.1%; NBW, 83.5%; HBW 10.5%; P < .0001). Children with HBW had significantly greater odds of having more severe steatosis (OR, 1.82, 95% CI. 1.15-2.88) and nonalcoholic steatohepatitis (OR, 2.03; 95% CI, 1.21-3.40) compared with children with NBW. In addition, children with NAFLD and LBW had significantly greater odds of having advanced fibrosis (OR, 2.23; 95% CI, 1.08-4.62).

Conclusion: Birth weight involves maternal and in utero factors that may have long-lasting consequences. Children with both LBW and HBW may be at increased risk for developing NAFLD. Among children with NAFLD, those with LBW or HBW appear to be at increased risk for more severe disease.

Keywords: birth weight; children; epidemiology; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; obesity.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

**Figure 1**
The distribution of birth weight in children with NAFLD compared to the general population. NAFLD is shown in light grey, and the US population is shown in black. Both LBW and HBW are significantly over-represented in children with NAFLD compared the general US population, (p value <0.0001).

See this image and copyright information in PMC

Comment in

The Highs and Lows of Fetal Programming for Fatty Liver Disease.
Mouzaki M, Ling SC. Mouzaki M, et al. J Pediatr. 2017 Aug;187:13-15. doi: 10.1016/j.jpeds.2017.03.062. Epub 2017 May 5. J Pediatr. 2017. PMID: 28483066 No abstract available.

References

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1. Lindback SM, Gabbert C, Johnson BL, Smorodinsky E, Sirlin CB, Garcia N, et al. Pediatric nonalcoholic fatty liver disease: a comprehensive review. Advances in pediatrics. 2010;57(1):85–140. - PubMed
1. Molleston JP, Schwimmer JB, Yates KP, Murray KF, Cummings OW, Lavine JE, et al. Histological abnormalities in children with nonalcoholic fatty liver disease and normal or mildly elevated alanine aminotransferase levels. The Journal of pediatrics. 2014 Apr;164(4):707–13 e3. - PMC - PubMed
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Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

Collaborators

Affiliations

Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

Comment in

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical