Stimulus-secretion coupling in angiotensin-stimulated adrenal glomerulosa cells
- PMID: 2836658
- DOI: 10.1016/0022-4731(88)90256-7
Stimulus-secretion coupling in angiotensin-stimulated adrenal glomerulosa cells
Abstract
Adrenal glomerulosa cell is a suitable model for a comparative study of signal transducing mechanisms since its secretory activity is regulated by at least three different mechanisms: the adenylate cyclase-cAMP system (for ACTH), the voltage-dependent Ca2+ channel (for K+ and perhaps for angiotensin II) and the inositol 1,4,5-trisphosphate-Ca2+ system (for angiotensin II and vasopressin). The role of inositol phosphates, extracellular Ca2+ and protein kinase C in the induction and sustaining of aldosterone production by cells exposed to angiotensin II is critically reviewed.
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