Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Apr-Jun;9(2):132-135.
doi: 10.4103/0974-2727.199639.

Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia infections

Priyam Batra  1 , Purva Mathur  1 , Mahesh C Misra  2
Affiliations

Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia infections

Priyam Batra et al. J Lab Physicians. 2017 Apr-Jun.

Abstract

Introduction: Stenotrophomonas maltophilia earlier had limited pathogenic potential, but now with growing degree of immunosuppression in general population, it is being recognized as an important nosocomial pathogen.

Methodology: A retrospective 7 years study was carried out to determine the clinical characteristics of all patients with Stenotrophomonas infections, antibiotic resistance pattern, and risk factors associated with hospital mortality. All patients with Stenotrophomonas culture positivity were identified and their medical records were reviewed. Risk factor associated with hospital mortality was analyzed.

Results: A total of 123 samples obtained from 88 patients were culture positive. Most patients presented with bacteremia (45, 51%) followed by pneumonia (37, 42%) and skin and soft tissue infections (6, 7%). About 23 of 88 Stenotrophomonas infected patients had co-infection. Percentage resistance to cotrimoxazole; 8 (5.4%) was lower than that for levofloxacin; 18 (12%). Twenty-eight patients died during hospital stay. Intensive Care Unit admission (P = 0.0002), mechanical ventilation (P = 0.0004), central venous catheterization (P = 0.0227), urethral catheterization (P = 0.0484), and previous antibiotic intake (P = 0.0026) were independent risk factors associated with mortality.

Conclusion: Our findings suggest that Stenotrophomonas can cause various infections irrespective of patient's immune status and irrespective of potential source. Thus, Stenotrophomonas should be thought of as potential pathogen and its isolation should be looked with clinical suspicion.

Keywords: Epidemiology; Stenotrophomonas; risk factors.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

References

    1. Low CY, Rotstein C. Emerging fungal infections in immunocompromised patients. F1000 Rep. 2011;3:14. - PMC - PubMed
    1. Wu H, Wang JT, Shiau YR, Wang HY, Lauderdale TL, Chang SC. TSAR Hospitals. A multicenter surveillance of antimicrobial resistance on Stenotrophomonas maltophilia in Taiwan. J Microbiol Immunol Infect. 2012;45:120–6. - PubMed
    1. Xun M, Zhang Y, Li BL, Wu M, Zong Y, Yin YM. Clinical characteristics and risk factors of infections caused by Stenotrophomonas maltophilia in a hospital in Northwest China. J Infect Dev Ctries. 2014;8:1000–5. - PubMed
    1. Naeem T, Absar M, Somily AM. Antibiotic resistance among clinical isolates of Stenotrophomonas maltophilia at a teaching hospital in Riyadh, Saudi Arabia. J Ayub Med Coll Abbottabad. 2012;24:30–3. - PubMed
    1. Chhablani J, Sudhalkar A, Jindal A, Das T, Motukupally SR, Sharma S, et al. Stenotrophomonas maltophilia endogenous endophthalmitis: Clinical presentation, antibiotic susceptibility, and outcomes. Clin Ophthalmol. 2014;8:1523–6. - PMC - PubMed