Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987;31(12):1209-15.
doi: 10.1111/j.1348-0421.1987.tb01354.x.

Differential expression of the major histocompatibility antigen complex (MHC) on a series of Burkitt's lymphoma lines

T Yokochi  1 , Y Inoue, H Iwata, T Miyadai, Y Kimura
Affiliations

Differential expression of the major histocompatibility antigen complex (MHC) on a series of Burkitt's lymphoma lines

T Yokochi et al. Microbiol Immunol. 1987.

Abstract

We compared the expressions of class I and class II major histocompatibility antigen complex (MHC) on the surface of Jijoye and P3HR-1 cells of Burkitt's lymphoma sublines. Jijoye cells had a large amount of class I and class II MHC antigens, whereas these antigens were less expressed on P3HR-1 cells. On a subline of P3HR-1 K cells the expression of class I antigen markedly diminished and class II antigen was undetectable. On the other hand, Jijoye, P3HR-1, and P3HR-1 K cell lines were confirmed to be Epstein-Barr virus (EBV) nonproducer, low producer, and high producer, respectively. The chemical activation of EBV genome by treating P3HR-1 cells with 12-O-tetradecanoyl phorbol-13 acetate (TPA) and n-butyrate resulted in inhibition of the expression of class I and II antigens, while the addition of retinoic acid, an inhibitor of virus replication, blocked the decrease in the MHC antigen expression. These findings suggested that there might be an inverse correlation between the virus production and the expression of class I and II MHC antigens.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Adams, A. 1979. The state of the virus genome in transformed cells and its relationship to host cell DNA, p. 155–183. In Epstein M.A., and Achong B.G. (eds), The Epstein‐Barr virus, Springer‐Verlag, Berlin, Heidelberg.
    1. Clark, E.A. , and Yokochi, T. 1984. Human B cell and B cell blast‐associated surface molecules defined with monoclonal antibodies, p. 339–346. In Bernard A., Boumsell L., Dausset J., Milstein C., and Schlossman S.F. (eds), Leukocyte typing, Springer‐Verlag, Berlin, Heidelberg.
    1. Gladstone, P. , and Pious, D. 1978. Stable variants affecting B cell alloantigens in human lymphoid cells. Nature 271: 459–461. - PubMed
    1. Hamper, B. 1979. Activation of the viral genome in vitro, p. 283–295. In Epstein M.A., and Achong B.G. (eds), The Epstein‐Barr virus, Springer‐Verlag, Berlin, Heidelberg.
    1. Heller, M. , Dambaugh, T. , and Kieff, E. 1981. Epstein‐Barr virus DNA. IX. Variation among viral DNAs from producer and nonproducer infected cells. J. Virol. 38: 632–648. - PMC - PubMed

Publication types

MeSH terms