How to Translate Time? The Temporal Aspect of Human and Rodent Biology

Affiliations

¹ Department of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, MD, USA; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Denes V Agoston. Front Neurol. 2017.

. 2017 Mar 17:8:92.

doi: 10.3389/fneur.2017.00092. eCollection 2017.

¹ Department of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, MD, USA; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

No abstract available

Keywords: differences; humans; mice; rats; species; time; translation.

References

1. Baker D, Amor S. Mouse models of multiple sclerosis: lost in translation? Curr Pharm Des (2015) 21(18):2440–52. 10.2174/1381612821666150316122706 - DOI - PubMed
1. Corbett D, Jeffers M, Nguemeni C, Gomez-Smith M, Livingston-Thomas J. Lost in translation: rethinking approaches to stroke recovery. Prog Brain Res (2015) 218:413–34. 10.1016/bs.pbr.2014.12.002 - DOI - PubMed
1. Schumacher M, Denier C, Oudinet JP, Adams D, Guennoun R. Progesterone neuroprotection: the background of clinical trial failure. J Steroid Biochem Mol Biol (2016) 160:53–66. 10.1016/j.jsbmb.2015.11.010 - DOI - PubMed
1. Talevi A, Bellera CL, Di Ianni M, Gantner M, Bruno-Blanch LE, Castro EA. CNS drug development – lost in translation? Mini Rev Med Chem (2012) 12(10):959–70. 10.2174/138955712802762356 - DOI - PubMed
1. Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 110(9):3507–12. 10.1073/pnas.1222878110 - DOI - PMC - PubMed