Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017;5(1):42-48.
doi: 10.1007/s40136-017-0144-6. Epub 2017 Mar 14.

Tissue-Engineered Larynx: Future Applications in Laryngeal Cancer

Nick J I Hamilton  1 , Martin A Birchall  1
Affiliations
Review

Tissue-Engineered Larynx: Future Applications in Laryngeal Cancer

Nick J I Hamilton et al. Curr Otorhinolaryngol Rep. 2017.

Abstract

Purpose of review: This article reviews the latest developments in tissue engineering for the larynx with a specific focus on the treatment of laryngeal cancer.

Recent findings: Challenges in tissue engineering a total larynx can be divided into scaffold design, methods of re-mucosalization, and how to restore laryngeal function. The literature described a range of methods to deliver a laryngeal scaffold including examples of synthetic, biomimetic, and biological scaffolds. Methods to regenerate laryngeal mucosa can be divided into examples that use a biological dressing and those that engineer a new mucosal layer de novo. Studies aiming to restore laryngeal function have been reported, but to date, the optimum method for achieving this as part of a total laryngeal transplant is yet to be determined.

Summary: There is great potential for tissue engineering to improve the treatments available for laryngeal cancer within the next 10 years. A number of challenges exist however and advances in restoring function must keep pace with developments in scaffold design.

Keywords: Laryngeal cancer; Larynx; Larynx transplant; Regenerative medicine; Tissue engineering.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest

The authors declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Figures

Fig. 1
Fig. 1
Tissue engineering buccal mucosa. a A biopsy of buccal mucosa is taken and the epithelial cells and fibroblasts separated. These cells are then expanded in culture and seeded onto a sheet of decellularized human dermis. The construct is then matured at air-liquid interface to promote differentiation. b A section of tissue-engineered buccal mucosa (BM) is sutured onto a decellularized hemilarynx (DL) in vitro to restore the mucosal layer in vitro
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cattaruzza MS, Maisonneuve P, Boyle P. Epidemiology of laryngeal cancer. Eur J Cancer B Oral Oncol. 1996;32B(5):293–305. doi: 10.1016/0964-1955(96)00002-4. - DOI - PubMed
    1. SEER Stat Fact Sheets: Larynx Cancer USA: National Cancer Institute 2016 [Available from: http://seer.cancer.gov/statfacts/html/laryn.html.
    1. Bajaj Y, Shayah A, Sethi N, Harris AT, Bhatti I, Awobem A, et al. Clinical outcomes of total laryngectomy for laryngeal carcinoma. Kathmandu Univ Med J (KUMJ) 2009;7(27):258–262. - PubMed
    1. Basheeth N, O'Leary G, Khan H, Sheahan P. Oncologic outcomes of total laryngectomy: impact of margins and preoperative tracheostomy. Head Neck. 2015;37(6):862–869. doi: 10.1002/hed.23681. - DOI - PubMed
    1. Pereira da Silva A, Feliciano T, Vaz Freitas S, Esteves S, Almeida ESC. Quality of life in patients submitted to total laryngectomy. J Voice. 2015;29(3):382–388. doi: 10.1016/j.jvoice.2014.09.002. - DOI - PubMed

LinkOut - more resources