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. 2017 Apr;5(2):73-82.

Regulation of Bone Metabolism

Maryam Shahi  1 , Amir Peymani  1 , Mehdi Sahmani  2
Affiliations

Regulation of Bone Metabolism

Maryam Shahi et al. Rep Biochem Mol Biol. 2017 Apr.

Abstract

Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation, and bone homeostasis are controlled by various markers and signaling pathways. Bone needs to be remodeled to maintain integrity with osteoblasts, which are bone-forming cells, and osteoclasts, which are bone-degrading cells.In this review we considered the major factors and signaling pathways in bone formation; these include fibroblast growth factors (FGFs), bone morphogenetic proteins (BMPs), wingless-type (Wnt) genes, runt-related transcription factor 2 (RUNX2) and osteoblast-specific transcription factor (osterix or OSX).

Keywords: BMP; FGF; OSX; Osteogenesis; RUNS2; Wnt.

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