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. 2017 Apr;19(4):416-422.
doi: 10.1080/10286020.2017.1307188.

Noralashinol B, a norlignan with cytotoxicity from stem barks of Syringa pinnatifolia

Rui-Fei Zhang  1   2 , Xiao Feng  1   2 , Guo-Zhu Su  1   2 , Xu Yin  1   2 , Xin-Yao Yang  1   2 , Yun-Fang Zhao  1 , Wei-Feng Li  2 , Peng-Fei Tu  1 , Xing-Yun Chai  1
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Noralashinol B, a norlignan with cytotoxicity from stem barks of Syringa pinnatifolia

Rui-Fei Zhang et al. J Asian Nat Prod Res. 2017 Apr.

Abstract

One new norlignan, noralashinol B (1), and one new natural product, proposed noralashinol C (2), were isolated in a continuous phytochemical investigation on the stem barks of Syringa pinnatifolia. Their structures were elucidated based on the analysis of spectroscopic data, including mass spectrometry and 1D and 2D NMR spectroscopies, and the absolute configuration was determined by experimental and calculated electronic circular dichroism. Compound 1 showed a weak cytotoxicity against HepG2 hepatic cancer cells with its IC50 value of 31.7 μM. Furthermore, 1 induced apoptosis of HepG2 cells in a dose-dependent manner at concentrations of 0-80.0 μM.

Keywords: Syringa pinnatifolia; calculated ECD; cytotoxicity; noralashinol B; noralashinol C; norlignan.

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