Systematic review of mammary analog secretory carcinoma of salivary glands at 7 years after description

Abstract

Background: Mammary analog secretory carcinoma of the salivary glands (MASC_SG ) is a newly introduced malignant tumor of the salivary glands. For decades, it has been confused with acinic cell carcinoma (ACC) of the salivary glands.

Methods: All reported cases of MASC_SG were surveyed from 2010 until January 2017. The collected data was compiled and computationally processed to describe the clinical parameters of MASC_SG . Its epidemiology was also mapped. Moreover, inaccurate data was highlighted.

Results: Clinically implicating, this article tackles simply the several clinical findings of MASC_SG so that our contemporary nosology, at 7 years after description, can be updated. The cytogenetic, histologic, and immunohistochemical details are also defined.

Conclusion: The available data about MASC_SG is sufficient enough to diagnose it with no need to investigate the ETV6-NTRK3 translocation. Although high-grade malignancy and distant metastases were rarely reported, a rapt attention should be paid both to the nature of this tumor and to the indicated close follow-up of such cases, especially when necrosis, increased mitotic activity, and other classic caveats are conspicuous. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1243-1248, 2017.

Keywords: mammary analog; salivary gland cancers; secretory carcinoma; systematic review.