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Case Reports
. 2017 Jul;8(4):363-364.
doi: 10.1111/1759-7714.12430. Epub 2017 Mar 31.

Video-assisted thoracoscopy in the management of intrapleural extravasation of cytotoxic chemotherapy

Victor J Aguirre  1 , Dylan Barnett  1 , Nikki Burdett  1 , Rohit Joshi  1 , Fabiano F Viana  1
Affiliations
Case Reports

Video-assisted thoracoscopy in the management of intrapleural extravasation of cytotoxic chemotherapy

Victor J Aguirre et al. Thorac Cancer. 2017 Jul.

Abstract

The extravasation of cytotoxic agents into subcutaneous tissue is a serious complication of chemotherapy. Unfortunately, if such extravasation occurs into the pleural space, limited data is available to guide appropriate management. We present the first report in the literature of video-assisted thoracoscopy combined with a topoisomerase II inhibitor and iron chelator, dexrazoxane, in the successful management of this complication.

Keywords: Anthracycline toxicity; chemotherapy complication; dexrazoxane; mal-positioned central line; video-assisted thoracoscopy.

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Figures

Figure 1
Figure 1
Chest X ray confirming the position of the central venous catheter.
Figure 2
Figure 2
Fluoroscopy contrast study showing the tip of the catheter (arrow) draining into the pleural space and thoracoscopy image confirming the tip of the catheter lodged in the pleural space.
See this image and copyright information in PMC

References

    1. Curtit E, Chaigneau L, Pauchot J et al. Extravasation of liposomal doxorubicin induces irritant reaction without vesicant injury. Anticancer Res 2012; 32: 1481–3. - PubMed
    1. Schrijvers DL. Extravasation: A dreaded complication of chemotherapy. Ann Oncol 2003; 14 (Suppl. 3): iii26–30. - PubMed
    1. Mouridsen HT, Langer SW, Buter J et al. Treatment of anthracycline extravasation with Savene (dexrazoxane): Results from two prospective clinical multicentre studies. Ann Oncol 2007; 18: 546–50. - PubMed
    1. Viale PH. Complications associated with implantable vascular access devices in the patient with cancer. J Infus Nurs 2003; 26: 97–102. - PubMed
    1. Thomas CJ, Butler CS. Delayed pneumothorax and hydrothorax with central venous catheter migration. Anaesthesia 1999; 54: 987–90. - PubMed

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