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Comment
. 2017 Apr 1;96(4):829-830.
doi: 10.1093/biolre/iox016.

Mark it for destruction: a novel role of mRNA methylation in maternal-to-zygotic transition†

Wei Yan  1   2
Affiliations
Comment

Mark it for destruction: a novel role of mRNA methylation in maternal-to-zygotic transition†

Wei Yan. Biol Reprod. .
No abstract available

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Figures

Figure 1.
Figure 1.
Schematic illustration of the role of m6A in the regulation of maternal transcript turnover during MZT in zebrafish. Wild-type (WT) eggs contain a large number of m6A-marked maternal transcripts, which will degrade in a YTHDF2-dependent manner during MZT. The ythdf2 knockout (KO) eggs lack YTHDF2 and thus, m6A-marked maternal transcripts fail to be removed and the persistent maternal transcripts disrupt normal MZT, leading to a complete block in late G2 and early M phase of the cell cycle in one-cell embryos.
See this image and copyright information in PMC

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