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Review
. 2017 Apr;156(4_suppl):S41-S50.
doi: 10.1177/0194599816685559.

Panel 3: Genetics and Precision Medicine of Otitis Media

Jizhen Lin  1 , Lena Hafrén  2 , Joseph Kerschner  3 , Jian-Dong Li  4 , Steve Brown  5 , Qing Y Zheng  6 , Diego Preciado  7 , Yoshihisa Nakamura  8 , Qiuhong Huang  9 , Yan Zhang  10
Affiliations
Review

Panel 3: Genetics and Precision Medicine of Otitis Media

Jizhen Lin et al. Otolaryngol Head Neck Surg. 2017 Apr.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Otolaryngol Head Neck Surg. 2017 Dec;157(6):1081. doi: 10.1177/0194599817731766. Epub 2017 Sep 19. Otolaryngol Head Neck Surg. 2017. PMID: 28925319

Abstract

Objective The objective is to perform a comprehensive review of the literature up to 2015 on the genetics and precision medicine relevant to otitis media. Data Sources PubMed database of the National Library of Medicine. Review Methods Two subpanels were formed comprising experts in the genetics and precision medicine of otitis media. Each of the panels reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a merged draft was created. The entire panel met at the 18th International Symposium on Recent Advances in Otitis Media in June 2015 and discussed the review and refined the content. A final draft was made, circulated, and approved by the panel members. Conclusion Many genes relevant to otitis media have been identified in the last 4 years in advancing our knowledge regarding the predisposition of the middle ear mucosa to commensals and pathogens. Advances include mutant animal models and clinical studies. Many signaling pathways are involved in the predisposition of otitis media. Implications for Practice New knowledge on the genetic background relevant to otitis media forms a basis of novel potential interventions, including potential new ways to treat otitis media.

Keywords: genetics; otitis media; precision medicine.

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Conflict of interest statement

Competing interests: Joseph Kerschner, AventaMed—scientific advisor; Steve Brown, Audition Therapeutics Ltd—co–chief scientific officer, shareholder; Pulmagen Therapeutics Ltd—shareholder; CNR Monterotondo, Rome—consultant.

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