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. 1988 Apr;69(2):321-6.

Alpha-1-antitrypsin hepatic cell globules in autotransplanted liver of rats

A P Jayaraj  1
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Alpha-1-antitrypsin hepatic cell globules in autotransplanted liver of rats

A P Jayaraj. Br J Exp Pathol. 1988 Apr.

Abstract

The autotransplantation of liver into the subcutaneous tissues in rats and hamsters resulted in the development of periodic acid Schiffs staining positive granules, which were resistant to diastase digestion. These granules were confirmed as alpha-1-antitrypsin by immunohistochemical staining. The appearance of the alpha-1-antitrypsin containing hepatic granules is comparable to those seen in the liver of humans with genetically determined alpha-1-antitrypsin deficiency.

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