Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2017 Dec:190:90-95.
doi: 10.1016/j.schres.2017.03.043. Epub 2017 Mar 31.

Comorbid diagnoses for youth at clinical high risk of psychosis

Jean Addington  1 , Danijela Piskulic  2 , Lu Liu  2 , Jonathan Lockwood  2 , Kristin S Cadenhead  3 , Tyrone D Cannon  4 , Barbara A Cornblatt  5 , Thomas H McGlashan  6 , Diana O Perkins  7 , Larry J Seidman  8 , Ming T Tsuang  9 , Elaine F Walker  10 , Carrie E Bearden  11 , Daniel H Mathalon  12 , Scott W Woods  6
Affiliations
Multicenter Study

Comorbid diagnoses for youth at clinical high risk of psychosis

Jean Addington et al. Schizophr Res. 2017 Dec.

Abstract

Several studies have demonstrated that youth at clinical high risk (CHR) of developing psychosis have a high prevalence of comorbid psychiatric disorders. Less is known about the impact of comorbid diagnoses on later conversion to psychosis and the change over time. The aim of this study was to determine the frequency and distribution of psychiatric diagnoses at baseline and over time in the North American Prodrome Longitudinal Study (NAPLS 2) and the role of comorbid diagnoses in conversion to psychosis. The NAPLS 2 sample consisted of 744 CHR youth and 276 healthy controls. Only 21% of the CHR group did not have a comorbid diagnosis with many have 2-3 DSM-IV comorbid diagnoses. The most common diagnoses were anxiety and depressive disorders, which did improve over time. The only diagnosis at baseline that differentiated the converters from the non-converters was cannabis misuse. Comorbidity, except for cannabis use, was essentially independent of clinical outcome. It is possible that those with comorbid diagnoses are preferentially the help-seeking individuals that present for help in our clinics and research projects and that those who are at risk but do not have a comorbid diagnosis may not be seeking help in the prodromal phase.

Keywords: Anxiety; Clinical high risk; Comorbidity; DSM-IV diagnoses; Depression.

PubMed Disclaimer

Conflict of interest statement

Author Conflicts of Interest

Dr. Cannon reports that he is a consultant to the Los Angeles County Department of Mental Health and to Boehringer Ingelheim Pharmaceuticals.

Dr. Woods reports that since 2005 he has received investigator-initiated research funding support from UCB Pharma, Glytech, Lilly, Bristol-Myers Squibb, and Pfizer. He has received sponsor-initiated research funding support from Kali-Duphar, Zeneca, Sandoz, Janssen, Auspex, and Teva and has consulted to Otsuka, Schering-Plough, Merck, Biomedisyn (unpaid), and Boehringer-Ingelheim and has received grants from NIMH, NARSAD, and the Donaghue Foundation. He has also served as an unpaid consultant to DSM-5. He has been granted US patent no. 8492418 B2 for a method of treating prodromal schizophrenia with glycine agonists, is an inventor on a patent pending for a method of predicting psychosis risk using blood biomarker analysis, and has received royalties from Oxford University Press.

All other authors report no conflicts.

References

    1. Addington J, Cadenhead KS, Cornblatt BA, Mathalon DH, McGlashan TH, Perkins DO, Seidman LJ, Tsuang MT, Walker EF, Woods SW, Addington JA, Cannon TD. North American Prodrome Longitudinal Study (NAPLS 2): Overview and recruitment. Schizophr Res. 2012;142(1–3):77–82. - PMC - PubMed
    1. Addington J, Liu L, Buchy L, Cadenhead KS, Cannon TD, Cornblatt BA, Perkins DO, Seidman LJ, Tsuang MT, Walker EF, Woods SW, Bearden CE, Mathalon DH, McGlashan TH. North American Prodrome Longitudinal Study (NAPLS 2): The Prodromal Symptoms. J Nerv Ment Dis. 2015;203(5):328–335. - PMC - PubMed
    1. Buchy L, Seidman LJ, Cadenhead KS, Cannon TD, Cornblatt BA, McGlashan TH, Perkins DO, Stone W, Tsuang MT, Walker EF, Woods SW, Bearden CE, Mathalon DH, Addington J. Evaluating the relationship between cannabis use and IQ in youth and young adults at clinical high risk of psychosis. Psychiatry Res. 2015;230(3):878–884. - PMC - PubMed
    1. Burton P, Gurrin L, Sly P. Extending the simple linear regression model to account for correlated responses: an introduction to generalized estimating equations and multi-level mixed modelling. Stat Med. 1998;17(11):1261–1291. - PubMed
    1. Diggle PJ, Liang KY, Zeger SL. Analysis of Longitudinal data. Oxford University Press; Oxford, United Kingdom: 1994.

Publication types