Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 May;23(5):377-378.
doi: 10.1016/j.molmed.2017.03.005. Epub 2017 Mar 31.

KRAS Allelic Imbalance: Strengths and Weaknesses in Numbers

Gary J Doherty  1 , Emma M Kerr  2 , Carla P Martins  3
Affiliations
Comment

KRAS Allelic Imbalance: Strengths and Weaknesses in Numbers

Gary J Doherty et al. Trends Mol Med. 2017 May.

Abstract

The identification of therapeutic vulnerabilities in mutant KRAS tumors has proven difficult to achieve. Burgess and colleagues recently reported in Cell that mutant/wild-type Kras allelic dosage determines clonal fitness and MEK inhibitor sensitivity in a leukemia model, demonstrating that KRAS allelic imbalance is likely an important and overlooked variable.

PubMed Disclaimer

Comment on

  • KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
    Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Young A, Lacap JA, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor BS, Evangelista M, Shannon K. Burgess MR, et al. Cell. 2017 Feb 23;168(5):817-829.e15. doi: 10.1016/j.cell.2017.01.020. Epub 2017 Feb 16. Cell. 2017. PMID: 28215705 Free PMC article.

MeSH terms

LinkOut - more resources