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. 2017 Feb;29(1):86-92.
doi: 10.21147/j.issn.1000-9604.2017.01.10.

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in treatment of gastric cancer with peritoneal carcinomatosis

Lynne M Ellison  1 , Yangao Man  1 , Alexander Stojadinovic  1 , Hongwu Xin  2 , Itzhak Avital  1
Affiliations

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in treatment of gastric cancer with peritoneal carcinomatosis

Lynne M Ellison et al. Chin J Cancer Res. 2017 Feb.

Abstract

Although gastric cancer with peritoneal carcinomatosis is associated with poor prognosis and is generally treated with palliative systemic therapy, recent studies have shown that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may prove to be an efficacious treatment option. In addition to reviewing the natural history of gastric cancer with peritoneal carcinomatosis, this mini-review examines literature on the efficacy of CRS and HIPEC as compared to chemotherapy and surgical options. Both randomized and non-randomized studies were summarized with the emphasis focused on overall survival. In summary, CRS and HIPEC are indeed a promising treatment option for gastric cancer with peritoneal carcinomatosis and large randomized clinical trials are warranted.

Keywords: Cytoreductive surgery; hyperthermic intraperitoneal chemotherapy; peritoneal carcinomatosis.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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