Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2018 Jan;32(1):e22222.
doi: 10.1002/jcla.22222. Epub 2017 Apr 4.

A link between platelet to lymphocyte ratio and Helicobacter pylori infection

Raymond Farah  1   2 , Hamza Hamza  3 , Rola Khamisy-Farah  4
Affiliations
Randomized Controlled Trial

A link between platelet to lymphocyte ratio and Helicobacter pylori infection

Raymond Farah et al. J Clin Lab Anal. 2018 Jan.

Abstract

Purpose: Chronic Helicobacter pylori gastritis affects two-thirds of the world's population and is one of the most common chronic inflammatory disorders of humans, the infection clearly results in chronic mucosal inflammation in the stomach and duodenum, which, in turn, might lead to abnormalities in gastroduodenal motility and sensitivity and is the most frequent cause of dyspepsia and peptic disease. Some studies showed that there was a correlation between low-grade inflammation as CRP and HP infection. The purpose of this study was to investigate the relationship between the presence of HP infection and platelet/lymphocyte ratio (PLR).

Method: A total of 200 patients who met the HP criteria and 180 age- and gender-matched control subjects were included in this randomized controlled trial. Patients were diagnosed to have HP according stomach biopsy and urea breath test, PLR was calculated from complete blood count at time of diagnosis and before initiating the treatment.

Results: Patients with HP infection had significantly higher PLR compared to those without HP. Moreover, the patients with symptomatic HP had higher PLR than those with asymptomatic HP. While PLR increased as the severity of HP symptoms increased (r=.452, P<.001).

Conclusion: Our study indicated, for the first time, a significant association between HP infection and symptoms based on PLR, a simple and reliable indicator of inflammation. Furthermore, there an increase in PLR as the severity of HP increases.

Keywords: Helicobacter pylori; inflammation; peptic disease; platelet/lymphocyte ratio.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Differences between all groups
See this image and copyright information in PMC

References

    1. Cave DR. Transmission and epidemiology of Helicobacter pylori . Am J Med. 1996;100:12S‐17S; discussion 17S–18S. - PubMed
    1. Pounder RE, Ng D. The prevalence of Helicobacter pylori infection in different countries. Aliment Pharmacol Ther. 1995;9(suppl 2):33‐39. - PubMed
    1. Linz B, Balloux F, Moodley Y, et al. An African origin for the intimate association between humans and Helicobacter pylori . Nature. 2007;445:915‐918. - PMC - PubMed
    1. Mégraud F. Transmission of Helicobacter pylori: faecal‐oral versus oral‐oral route. Aliment Pharmacol Ther. 1995;9(suppl 2):85‐91. - PubMed
    1. Perry S, de la Luz Sanchez M, Yang S, et al. Gastroenteritis and transmission of Helicobacter pylori infection in households. Emerg Infect Dis. 2006;12:1701‐1708. - PMC - PubMed

Publication types