Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Apr 4;10(1):146.
doi: 10.1186/s13104-017-2465-4.

Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes

Daya Ram Pokharel  1 , Dipendra Khadka  2 , Manoj Sigdel  3 , Naval Kishor Yadav  3 , Shreedhar Acharya  4 , Ramchandra Kafle  5 , Ravindra Mohan Sapkota  6 , Tara Sigdel  7
Affiliations

Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes

Daya Ram Pokharel et al. BMC Res Notes. .

Abstract

Background: Atherogenic dyslipidemia is an important modifiable risk factor for cardiovascular disease among patients of type 2 diabetes mellitus. Timely detection and characterization of this condition help clinicians estimate future risk of cardiovascular disease and take appropriate preventive measures. The aim of this study was to determine the prevalence, pattern and predictors of dyslipidemia in a cohort of Nepalese patients with type 2 diabetes.

Results: We found mixed dyslipidemia as the most prevalent (88.1%) and isolated dyslipidemia (10.1%) as the least prevalent forms of dyslipidemia in our patients. The most prevalent form of single dyslipidemia was high LDL-C (73.8%) and combined dyslipidemia was high TG, high LDL-C and low HDL-C (44.7%). Prevalence of all single and mixed dyslipidemia was higher in patients with poor glycemic control and hypertension. The glycemic status of patients correlated with their fasting serum lipid profile. Dyslipidemia was associated mainly with male gender, poor glycemic control and hypertension.

Conclusions: Atherogenic dyslipidemia is associated mainly with male gender, poor glycemic control and hypertension. It is highly prevalent in Nepalese patients with type 2 diabetes. Urgent lifestyle modification, sustained glycemic control and aggressive lipid lowering treatment plans are necessary to minimize the future risk of cardiovascular disease in this population.

Keywords: Cardiovascular disease; Dyslipidemia; Nepal; Pokhara; Prevalence; Type 2 diabetes.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Age- and sex specific mean values of serum lipid parameters and their ratio in diabetic patients. Student's t-test was used to compare the group means of female (I) and male (II) patients. One-way ANOVA was used for comparing serum levels of single lipid parameter within three different age groups (30–44, 45–59 and 60–74). ***p for trend <0.001, **p for trend <0.010 *p for trend <0.05 (two tailed). TG, triglycerides; TC, total cholesterol; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; ApoB, apolipoprotein B. Mean refers to the serum mean concentrations and ratio of lipid parameters
Fig. 2
Fig. 2
Venn diagram showing the overlapping of the individual components of dyslipidemia (hypertriglyceridemia, hypercholesterolemia, high LDL-C and low HDL-C) in diabetic patients
See this image and copyright information in PMC

References

    1. Bhandari GP, Angdembe MR, Dhimal M, Neupane S, Bhusal C. State of non-communicable diseases in Nepal. BMC Public Health. 2014;14:23. doi: 10.1186/1471-2458-14-23. - DOI - PMC - PubMed
    1. Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III) JAMA. 2001;285:2486–2497. doi: 10.1001/jama.285.19.2486. - DOI - PubMed
    1. Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Type 2 diabetes as a “coronary heart disease equivalent”: an 18-year prospective population-based study in Finnish subjects. Diabetes Care. 2005;28:2901–2907. doi: 10.2337/diacare.28.12.2901. - DOI - PubMed
    1. Mooradian AD. Cardiovascular disease in type 2 diabetes mellitus: current management guidelines. Arch Intern Med. 2003;163:33–40. doi: 10.1001/archinte.163.1.33. - DOI - PubMed
    1. Krauss RM. Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care. 2004;27:1496–1504. doi: 10.2337/diacare.27.6.1496. - DOI - PubMed

MeSH terms

LinkOut - more resources