doi: 10.1093/nar/16.10.4331.
Chromosome size polymorphism in Plasmodium falciparum can involve deletions of the subtelomeric pPFrep20 sequence
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- PMID: 2837730
- PMCID: PMC336633
- DOI: 10.1093/nar/16.10.4331
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Chromosome size polymorphism in Plasmodium falciparum can involve deletions of the subtelomeric pPFrep20 sequence
Nucleic Acids Res.
.
Free PMC article
Abstract
The P. falciparum pPFrep20 repetitive element from the Palo Alto Uganda strain has been isolated and sequenced. The Palo Alto pPFrep20 repeat (pPFPArep20) has a clustered subtelomeric location and on chromosome 1 has been deleted from one end. Analysis of chromosome 1 from 5 other strains has revealed that pPFrep20 sequences have been deleted from one end in 3 of them. Thus, deletion of pPFrep20 appears to be a frequent event that could significantly contribute to chromosome size polymorphism in P. falciparum.
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