[Confocal microscope examination of the corneal nerve plexus as biomarker for systemic diseases : View from the corneal nerve plexus on diabetes mellitus disease]

Abstract

It is estimated that approximately 50% of patients with diabetes mellitus suffer from polyneuropathy, which is frequently diagnosed too late. Consequently, the question arises whether imaging procedures of the eye, namely optical coherence tomography of the retina and confocal microscopy of the cornea are suitable for the diagnostics and follow-up control of neurodegenerative changes in patients with diabetes mellitus. De Clerck and co-workers could demonstrate this by a systematic review of studies. Of these studies 11 were further evaluated with respect to corneal confocal microscopy. Approximately 15 years after juvenile type 1 diabetes a reduction of corneal nerve fiber length and density was observed, although clinical signs of neuropathy were absent. At this stage an examination seems reasonable. Type 2 diabetes mellitus in the elderly is often associated with a metabolic syndrome and its time of manifestation remains unknown; therefore, corneal confocal microscopy should be implemented at the time of diagnosis of type 2 diabetes. Patients with long disease duration and significant changes in the corneal nerve plexus already showed clinical signs of polyneuropathy and often suffered from proliferative retinopathy. The accessibility of the eye for non-invasive optical modalities should be used more often in the treatment of patients with diabetes mellitus for early identification of patients at risk. Further longitudinal studies are highly necessary.

Keywords: Diabetic retinopathy; Follow-up control; Imaging; Optical coherence tomography; Polyneuropathy.