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. 2017 Nov;27(6):846-850.
doi: 10.1111/bpa.12455. Epub 2017 Apr 5.

H3 K27M Mutation in Gangliogliomas can be Associated with Poor Prognosis

B K Kleinschmidt-DeMasters  1 , Andrew Donson  2 , Nicholas K Foreman  2 , Kathleen Dorris  2
Affiliations

H3 K27M Mutation in Gangliogliomas can be Associated with Poor Prognosis

B K Kleinschmidt-DeMasters et al. Brain Pathol. 2017 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Pediatric gangliogliomas at autopsy. a–d. From patient 7—It shows the cervical spinal cord location (a, magnetic resonance imaging T1 with contrast, intraoperative photograph), WHO grade I features with numerous neoplastic ganglion cells (b, arrowheads) and basophilic microcalcifications (hematoxylin and eosin [H&E]), binucleated, neurofilament‐immunoreactive (phosphorylated NFP) neoplastic neurons (c), and H3 K27M immunoreactivity (d, with numerous interspersed microcalcifications archetypal for GG at arrowheads). e–g. From patient 8—It illustrates the patient's pontine GG (e, magnetic resonance imaging T2), tumoral neoplastic neurons (arrowheads) and microcalcifications (d, H&E), and H3 K27M immunoreactivity (e, with possible neoplastic ganglion cell at arrowhead). h–j. From patient 9—It shows that despite massive dissemination at autopsy to basilar leptomeninges (f, arrowhead), with encasement of spinal cord (g, whole mount, H&E), the tumor is nevertheless negative for H3 K27M by immunohistochemistry (j).
See this image and copyright information in PMC

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