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Comment
. 2017 Apr 4;25(4):757-758.
doi: 10.1016/j.cmet.2017.03.020.

Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect

Joel F Habener  1 , Violeta Stanojevic  2
Affiliations
Free article
Comment

Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect

Joel F Habener et al. Cell Metab. .
Free article

Abstract

The gut is believed to be the source of GLP-1 that augments insulin secretion in response to oral nutrients. In this issue of Cell Metabolism, Chambers et al. (2017) shift the paradigm by finding that GLP-1 produced within the islets of the pancreas, and not the gut, is responsible for the incretin effect in mice.

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  • The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.
    Chambers AP, Sorrell JE, Haller A, Roelofs K, Hutch CR, Kim KS, Gutierrez-Aguilar R, Li B, Drucker DJ, D'Alessio DA, Seeley RJ, Sandoval DA. Chambers AP, et al. Cell Metab. 2017 Apr 4;25(4):927-934.e3. doi: 10.1016/j.cmet.2017.02.008. Epub 2017 Mar 16. Cell Metab. 2017. PMID: 28325479 Free PMC article.

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