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Comment
. 2017 Apr 5;9(384):e2773.
doi: 10.1126/scitranslmed.aan2773.

Double trouble for CML

Kristopher Sarosiek  1
Affiliations
Comment

Double trouble for CML

Kristopher Sarosiek. Sci Transl Med. .

Abstract

Combining two BCR-ABL1 inhibitors with nonoverlapping mechanisms of action eradicates CML and prevents recurrence.

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  • The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
    Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR. Wylie AA, et al. Nature. 2017 Mar 30;543(7647):733-737. doi: 10.1038/nature21702. Epub 2017 Mar 22. Nature. 2017. PMID: 28329763

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