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Review
. 2017 Feb;10(2):127-135.
doi: 10.1177/1756285616677005. Epub 2016 Nov 16.

Botulinum toxin in the management of chronic migraine: clinical evidence and experience

Claus M Escher  1 , Lejla Paracka  2 , Dirk Dressler  2 , Katja Kollewe  3
Affiliations
Review

Botulinum toxin in the management of chronic migraine: clinical evidence and experience

Claus M Escher et al. Ther Adv Neurol Disord. 2017 Feb.

Abstract

Chronic migraine (CM) is a severely disabling neurological condition characterized by episodes of pulsating unilateral or bilateral headache. The United States Food and Drug Administration (FDA) approved onabotulinumtoxinA (Botox®) for the prophylactic treatment of CM in 2010. It has been shown that onabotulinumtoxinA is effective in the reduction of headache frequency and severity in patients with CM. Treatment is well tolerated by the patients. This review reports on the history of botulinum neurotoxin (BoNT) in CM and presents the current clinical evidence for the use of onabotulinumtoxinA in the treatment of CM.

Keywords: Botox®; botulinum neurotoxin; chronic daily headache; chronic migraine; onabotulinumtoxinA.

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Conflict of interest statement

Conflict of interest statement: CE states that he has no conflict of interest. LP received travel grants from Ipsen (Boulogne-Billancourt, France) and Merz (Frankfurt/M, Germany). DD received honoraria for consultations from Allergan (Irvine, California, USA), Bayer (Leverkusen, Germany), Eisai (Tokio, Japan), IAB-Interdisciplinary Working Group for Movement Disorders (Hamburg, Germany), Ipsen, Merz and UCB (Monheim, Germany). He is shareholder of Allergan and holds several patents on botulinum toxins. KK received travel grants and honoraria for lectures from Allergan, Ipsen and Merz.

References

    1. Adams A.M., Serrano D., Buse D.C., Reed M.L., Marske V., Fanning K.M., et al. (2015) The impact of chronic migraine: The Chronic Migraine Epidemiology and Outcomes (CaMEO) Study methods and baseline results. Cephalalgia 35: 563–578. - PMC - PubMed
    1. Ahmed F., Zafar H., Buture A., Khalil M. (2015) Does analgesic overuse matter? Response to OnabotulinumtoxinA in patients with chronic migraine with or without medication overuse. Springerplus 4: 589. - PMC - PubMed
    1. Aoki K. (2003) Evidence for antinociceptive activity of botulinum toxin type A in pain management. Headache 43(Suppl. 1): S9–15. - PubMed
    1. Aurora S., Dodick D., Diener H., DeGryse R., Turkel C., Lipton R., et al. (2014) OnabotulinumtoxinA for chronic migraine: efficacy, safety, and tolerability in patients who received all five treatment cycles in the PREEMPT clinical program. Acta Neurol Scand 129: 61–70. - PMC - PubMed
    1. Aurora S., Dodick D., Turkel C., DeGryse R., Silberstein S., Lipton R., et al. (2010) OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trial. Cephalgia 30: 793–803. - PubMed

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