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Review
. 2017 Jun;8(3):459-473.
doi: 10.1007/s13300-017-0258-3. Epub 2017 Apr 5.

Resistance Training for Glycemic Control, Muscular Strength, and Lean Body Mass in Old Type 2 Diabetic Patients: A Meta-Analysis

JungHoon Lee  1 , DoHoun Kim  2 , ChangKeun Kim  3
Affiliations
Review

Resistance Training for Glycemic Control, Muscular Strength, and Lean Body Mass in Old Type 2 Diabetic Patients: A Meta-Analysis

JungHoon Lee et al. Diabetes Ther. 2017 Jun.

Abstract

Introduction: Type 2 diabetes (T2D) in elderly patients is associated with accelerated loss of skeletal muscle mass and strength. However, there are few meta-analysis reviews which investigate the effects of resistance training (RT) on glycemic control and skeletal muscle in the patients.

Methods: Three electronic databases were searched (from the earliest date available to November 2016). Studies were included according to the inclusion criteria: T2D patients at least 60 years old, fasting plasma glucose of at least 7.0, and at least 8 weeks of RT.

Results: Fifteen cohorts of eight studies (360 patients, average age 66 years) met the inclusion criteria. RT groups lowered glycosylated hemoglobin (HbA1c) (mean ES = -0.37, 95% CI = -0.55 to -0.20, P < 0.01) but did not result in a significant effect on lean body mass (LBM) (mean ES = 0.08, 95% CI = -0.15 to 0.30, P = 0.50). Homogeneity was shown between studies regarding HbA1c and LBM (Q = 15.70, df = 9, P = 0.07 and Q = 0.12, df = 4, P = 0.998, respectively). High-intensity subgroups showed a slight tendency to improve (rather than duration, frequency, and weekly volume) and to decrease HbA1c levels more than low-intensity subgroups (P = 0.37). RT increased muscular strength (mean ES = 1.05, 95% CI = 0.26-1.84, P = 0.01). No training components explained the heterogeneity between studies with changes in muscle strength.

Conclusion: RT improves glycemic control and muscle strength in elderly patients with T2D. RT with high intensity can be a strategy to treat patients with T2D and sarcopenia associated with aging.

Keywords: Aging; Glycosylated hemoglobin; Insulin sensitivity; Sarcopenia.

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Figures

Fig. 1
Fig. 1
Forest plot of effect sizes and 95% confidence Intervals for all ten cohorts (8 studies) representing glycated hemoglobin, based on the fixed effects meta-analysis results. CON control group
Fig. 2
Fig. 2
Forest plot of effect sizes and 95% confidence intervals for all 4 cohorts (4 studies) representing muscular strength, based on the random effects meta-analysis results
Fig. 3
Fig. 3
Forest plot of effect sizes and 95% confidence intervals for all five cohorts (4 studies) representing lean body mass, based on the fixed effects meta-analysis results. CON control group
See this image and copyright information in PMC

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