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. 2017 Jun 7;23(32):7653-7656.
doi: 10.1002/chem.201700539. Epub 2017 May 15.

Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings

Gao-Wei Li  1 , Jiang-Ming Cao  1 , Wen Zong  2 , Li Hu  2 , Mao-Lin Hu  2 , Xinxiang Lei  3   2 , Han Sun  4 , Ren Xiang Tan  1
Affiliations

Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings

Gao-Wei Li et al. Chemistry. .

Abstract

Residual dipolar couplings (RDC) emerged to be an important structural parameter for organic and biomolecules. Herein, a new helical polyisocyanopeptide (l,l-PIAF-OBn) that forms lyotropic liquid crystals (LLC) in CDCl3 is proposed as a novel weakly orienting medium for acquiring residual dipolar couplings (RDCs) of organic molecules. We demonstrate its application for the structural elucidation of strychnine and triptolide.

Keywords: NMR spectroscopy; liquid crystals; polyisocyanodipeptides; residual dipolar couplings; small organic molecules.

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