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. 2017 Aug;106(8):1230-1238.
doi: 10.1111/apa.13868. Epub 2017 May 15.

Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes

Esther Castanys-Muñoz  1 , Kathy Kennedy  2 , Eurídice Castañeda-Gutiérrez  3 , Stewart Forsyth  4 , Keith M Godfrey  5 , Berthold Koletzko  6 , Susan E Ozanne  7 , Ricardo Rueda  8 , Marieke Schoemaker  9 , Eline M van der Beek  10   11 , Stef van Buuren  12   13 , Ken K Ong  14
Affiliations

Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes

Esther Castanys-Muñoz et al. Acta Paediatr. 2017 Aug.

Abstract

We systematically reviewed papers published in English between 1994 and October 2015 on how postnatal weight gain and growth affect neurodevelopment and metabolic outcomes in term-born small-for-gestational-age (SGA) infants. Two randomised trials reported that enriched infant formulas that promoted early growth also increased fat mass, lean mass and blood pressure (BP), but had no effect on early neurocognitive outcomes. Meanwhile, 31 observational studies reported consistent positive associations between postnatal weight gain and growth with neurocognitive outcomes, adiposity, insulin resistance and BP.

Conclusion: Few intervention studies exist, despite consistent positive associations between early growth and neurocognition in term-born SGA infants.

Keywords: Adiposity; Insulin resistance; Neurodevelopment; Postnatal growth; Small for gestational age.

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Figures

Figure 1
Figure 1
Flow chart of search strategy and selection of relevant studies.
See this image and copyright information in PMC

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