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. 1988;23(1):19-24.
doi: 10.1016/0531-5565(88)90016-2.

Age-related changes in rat liver plasma membrane sphingomyelinase activity

D H Petkova  1 , A B Momchilova-Pankova, T T Markovska, K S Koumanov
Affiliations

Age-related changes in rat liver plasma membrane sphingomyelinase activity

D H Petkova et al. Exp Gerontol. 1988.

Abstract

The age-induced changes of some phospholipid fractions, membrane fluidity and neutral membrane-bound sphingomyelinase (EC 3.1.4.12) activity in rat liver plasma membranes have been investigated. Alterations in the percentage participation of phosphatidylcholine and sphingomyelin with aging have been established. Regression analysis indicated a positive linear correlation (r = 0.927) between the membrane-bound neutral sphingomyelinase activity and the phosphatidylcholine percent in the total plasma membrane phospholipids, as well as a negative linear correlation (r = -0.937) between the enzyme activity and the sphingomyelin/phosphatidylcholine ratio.

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