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. 2017 Aug;36(8):758-760.
doi: 10.1097/INF.0000000000001597.

High Prevalence of Abacavir-associated L74V/I Mutations in Kenyan Children Failing Antiretroviral Therapy

Eric J Dziuban  1 , Joshua DeVos, Bernadette Ngeno, Evelyn Ngugi, Guoqing Zhang, Jennifer Sabatier, Nick Wagar, Karidia Diallo, Lucy Nganga, Abraham Katana, Chunfu Yang, Emilia D Rivadeneira, Irene Mukui, Francesca Odhiambo, Robert Redfield, Elliot Raizes
Affiliations

High Prevalence of Abacavir-associated L74V/I Mutations in Kenyan Children Failing Antiretroviral Therapy

Eric J Dziuban et al. Pediatr Infect Dis J. 2017 Aug.

Abstract

A survey of 461 HIV-infected Kenyan children receiving antiretroviral therapy found 143 (31%) failing virologically. Drug resistance mutations were found in 121; 37 had L74V/I mutations, with 95% receiving abacavir (ABC)-containing regimens. L74V/I was associated with current ABC usage (P = 0.0001). L74V/I may be more prevalent than previously realized in children failing ABC-containing regimens, even when time on treatment has been short. Ongoing rigorous pediatric drug resistance surveillance is needed.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

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