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Case Reports
. 1988 Apr;27(4):327-33.
doi: 10.1016/0028-2243(88)90046-9.

Interferon-alpha in treatment of intraepithelial neoplasia of the lower genital tract: a case report

B J Slotman  1 , T J Helmerhorst, P W Wijermans, J J Calame
Affiliations
Case Reports

Interferon-alpha in treatment of intraepithelial neoplasia of the lower genital tract: a case report

B J Slotman et al. Eur J Obstet Gynecol Reprod Biol. 1988 Apr.

Abstract

A patient with persistent intraepithelial neoplasia of the vulva, vagina and cervix was treated with subcutaneous injections of interferon-alpha-2b. Previous surgical and laser procedures had failed. HPV subtype 16 was found in biopsies from all sites and an immunological screening was performed before and after therapy. Histologically proven regression of the intraepithelial neoplasia was seen at all sites, with a complete remission of the cervical lesions. The role of interferon in treatment of intraepithelial neoplasia is discussed.

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