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Review
. 2017 Jul;10(4):242-248.
doi: 10.1111/cts.12466. Epub 2017 May 23.

Gene Therapy 2017: Progress and Future Directions

A M Keeler  1 , M K ElMallah  1 , T R Flotte  1
Affiliations
Review

Gene Therapy 2017: Progress and Future Directions

A M Keeler et al. Clin Transl Sci. 2017 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Timeline of major events in clinical gene therapy. A few selected key dates in the history of human gene therapy are depicted, with the dates indicated on the x‐axis. AAV2, adeno‐associated virus type 2; Ad5, adenovirus type 5; CF, cystic fibrosis; CRISPR, clustered regularly interspaced short palindromic repeats; FIX, clotting factor IX; LPL, lipoprotein lipase; OTC, ornithine transcambamylase; RNAi, RNA inhibition; RPE65, 65 kilo‐Dalton retinal pigment epithelial protein; RV, gammaretrovirus; SCID‐ADA, severe combined immune deficiency due to adenosine deaminase deficiency; TIL, tumor‐infiltrating lymphocytes.
Figure 2
Figure 2
Structure of adeno‐associated virus 2 (AAV2).113 The icosahedral structure of the virus capsid is shown. Note that this structure is symmetrical across a twofold, threefold, and fivefold axis of symmetry. The ability of the AAV vectors to transduce various cell types largely depends on variation in amino acid moieties highlighted in color.
See this image and copyright information in PMC

References

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