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Review
. 2017 Sep;284(18):2932-2946.
doi: 10.1111/febs.14078. Epub 2017 Apr 26.

ADP-ribosylation: new facets of an ancient modification

Luca Palazzo  1 , Andreja Mikoč  2 , Ivan Ahel  1
Affiliations
Review

ADP-ribosylation: new facets of an ancient modification

Luca Palazzo et al. FEBS J. 2017 Sep.

Abstract

Rapid response to environmental changes is achieved by uni- and multicellular organisms through a series of molecular events, often involving modification of macromolecules, including proteins, nucleic acids and lipids. Amongst these, ADP-ribosylation is of emerging interest because of its ability to modify different macromolecules in the cells, and its association with many key biological processes, such as DNA-damage repair, DNA replication, transcription, cell division, signal transduction, stress and infection responses, microbial pathogenicity and aging. In this review, we provide an update on novel pathways and mechanisms regulated by ADP-ribosylation in organisms coming from all kingdoms of life.

Keywords: ADP-ribosylation; cellular pathways; metabolism of ADP-ribosylation; poly(ADP-ribose) polymerase; post-translational modification.

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Conflict of interest statement

The authors have no conflicts of interest.

Figures

Figure 1
Figure 1
Targets and pathways involved in the metabolism of ADP‐ribose. Scheme is simplified to show only the main products and ADP‐ribose metabolites. Stars indicate reactions that use NAD +. PR, ribose‐5′‐phosphate.
See this image and copyright information in PMC

References

    1. Darwin C (1859) On the Origin of Species by Means of Natural Selection, or, the Preservation of Favoured Races in the Struggle for Life. J Murray, London. - PMC - PubMed
    1. Walsh C (2006) Posttranslational Modification of Proteins: Expanding Nature's Inventory. Roberts and Co. Publishers, Englewood, CO: XXI, pp. 490.
    1. Perina D, Mikoč A, Ahel J, Ćetković H, Žaja R & Ahel I (2014) Distribution of protein poly(ADP‐ribosyl)ation systems across all domains of life. DNA Repair (Amst) 23, 4–16. - PMC - PubMed
    1. Nakano T, Takahashi‐Nakaguchi A, Yamamoto M & Watanabe M (2015) Pierisins and CARP‐1: ADP‐ribosylation of DNA by ARTCs in butterflies and shellfish. Curr Top Microbiol Immunol 384, 127–149. - PubMed
    1. Jankevicius G, Ariza A, Ahel M & Ahel I (2016) The toxin‐antitoxin system DarTG catalyzes reversible ADP‐ribosylation of DNA. Mol Cell 64, 1109–1116. - PMC - PubMed

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