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Review
. 2017 Apr 6;13(4):e1006211.
doi: 10.1371/journal.ppat.1006211. eCollection 2017 Apr.

The role of integration in oncogenic progression of HPV-associated cancers

Alison A McBride  1 , Alix Warburton  1
Affiliations
Review

The role of integration in oncogenic progression of HPV-associated cancers

Alison A McBride et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Types of HPV integration.
A. Circular HPV genome. B. Linear HPV genome. URR (upstream regulatory region), PE (early promoter), and pAE and pAL (early and late polyadenylation sites) are indicated. The light blue circles in the URR represent E2 binding sites, and the dark blue square is the E1 binding site in the origin of replication (ori). C. In Type 1 integration, a single viral genome is integrated into the host DNA. In Type 2 integration, multiple genomes are integrated in tandem in a head-to-tail orientation. This often is accompanied by focal rearrangement and amplification of flanking cellular sequences.
Fig 2
Fig 2. Models of integration events that promote oncogenesis.
The five integration models shown in Table 1 are shown in the diagram, as indicated to the left. URR (upstream regulatory region), and PE (early promoter), are indicated. The light blue circles in the URR represent E2 binding sites, and the dark blue square is the E1 binding site in the origin of replication (ori).
See this image and copyright information in PMC

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