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. 2017 Apr 5;94(1):1-4.
doi: 10.1016/j.neuron.2017.03.032.

Huntington's Disease: Nuclear Gatekeepers Under Attack

Matthew B Veldman  1 , X William Yang  2
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Free article

Huntington's Disease: Nuclear Gatekeepers Under Attack

Matthew B Veldman et al. Neuron. .
Free article

Abstract

In this issue of Neuron, Gasset-Rosa et al. (2017) and Grima et al. (2017) describe defects in the nuclear pore complex and impaired nucleocytoplasmic transport in Huntington's disease (HD). The findings suggest that erosion of nuclear gatekeeping function, which is found in normal brain aging, may play an important role in the pathogenesis of multiple neurodegenerative disorders, including HD.

Keywords: Huntington’s disease; aging; neurodegeneration; nucleocytoplasmic transport.

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