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Comment
. 2017 Apr 5;94(1):4-5.
doi: 10.1016/j.neuron.2017.03.030.

SCA31 Flies Perform in a Balancing Act between RAN Translation and RNA-Binding Proteins

George R Jackson  1
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SCA31 Flies Perform in a Balancing Act between RAN Translation and RNA-Binding Proteins

George R Jackson. Neuron. .
Free article

Abstract

In this issue of Neuron, Ishiguro et al. (2017) explore the toxicity of RAN translation in spinocerebellar ataxia 31. Using a Drosophila model, the authors demonstrate that TDP-43 and other RNA-binding proteins act as chaperones to regulate the formation of toxic RNA aggregates.

Keywords: Drosophila; RNA chaperone; TDP-43; ataxia.

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