Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Feb;11(2):OC06-OC08.
doi: 10.7860/JCDR/2017/24764.9166. Epub 2017 Feb 1.

Golden Hours in Severe Paraquat Poisoning-The Role of Early Haemoperfusion Therapy

Raghavendra Rao  1 , Rama Bhat  2 , Swathi Pathadka  3 , Sravan Kumar Chenji  4 , Savio Dsouza  5
Affiliations

Golden Hours in Severe Paraquat Poisoning-The Role of Early Haemoperfusion Therapy

Raghavendra Rao et al. J Clin Diagn Res. 2017 Feb.

Abstract

Introduction: Paraquat is a commonly ingested poison especially in Southern India. There is no antidote for paraquat poison and consumption is often fatal. The usual cause of death is either acute lung injury or multi-organ failure.

Aim: To evaluate the role of early haemoperfusion as a therapy in paraquat poisoned patients.

Materials and methods: This study was a retrospective analysis of patients admitted to a Tertiary Medical College Hospital between January 2012 and December 2015 with history of paraquat consumption, comparing outcomes in those who received only gastric lavage and symptomatic treatment with those who received haemoperfusion as a therapy. The role of early haemoperfusion (≤ 6 hours) vs late haemoperfusion (> 6 hours) in paraquat poisoned patients was also compared. The data of these patients was extracted and analysed with respect to age, sex, mode of treatment, the outcome in patients who received early and late haemoperfusion.

Results: A total of 101 patients were studied out of which 62 died. Deaths were more in those patients who received only gastric lavage with symptomatic treatment as therapy compared to those who received haemoperfusion i.e., 92.1% vs 42.9% respectively. We also found that, the survival rate was better in patients who received early haemoperfusion.

Conclusion: Early haemoperfusion was helpful in the management of severe paraquat poisoning and improved the survival rate in these patients.

Keywords: Acute lung injury; Detoxification; Extracorporeal; Herbicide; Toxicological.

PubMed Disclaimer

Figures

[Table/Fig-5]:
[Table/Fig-5]:
Pie chart showing the cause of death in paraquat poisoned patients. ALI- Acute Lung Injury
See this image and copyright information in PMC

References

    1. Gunnell D, Eddleston M, Philips MR, Konradsen F. The global distribution of fatal pesticide self-poisoning : systematic review. BMC Public Health. 2007;7:357. - PMC - PubMed
    1. Sandhu JS, Dhiman A, Mahajan R, Sandhu P. Outcome of paraquat poisoning - a five year study. Indian J Nephrol. 2003;13:64–68.
    1. Suh GJ, Lee CC, Jo IJ, Shin SD, Lee JC, Min BG, Singer AJ. Haemoperfusion using dual pulsatile pump in paraquat poisoning. Am J Emerg Med. 2008;26(6):641–48. - PubMed
    1. Hong SY, Yang JO, Lee EY, Kim SH. Effect of haemoperfusion on plasma paraquat concentration in vitro and in vivo. ToxicolInd Health. 2003;19(1):17–23. - PubMed
    1. Pond SM, Rivory LP, Hampson EC, Roberts MS. Kinetics of toxic doses of paraquat and the effects of haemoperfusion in the dog. J Toxicol Clin Toxicol. 1993;31:229–46. - PubMed

LinkOut - more resources