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. 2017 Jul;102(7):e253-e256.
doi: 10.3324/haematol.2016.157669. Epub 2017 Apr 6.

Role of miR-15a/miR-16-1 and the TP53 axis in regulating telomerase expression in chronic lymphocytic leukemia

Enrica Rampazzo  1 , Engin Bojnik  1 , Livio Trentin  2 , Laura Bonaldi  3 , Paola Del Bianco  3 , Federica Frezzato  2 , Andrea Visentin  2 , Monica Facco  2 , Gianpietro Semenzato  2 , Anita De Rossi  4   3
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Role of miR-15a/miR-16-1 and the TP53 axis in regulating telomerase expression in chronic lymphocytic leukemia

Enrica Rampazzo et al. Haematologica. 2017 Jul.
No abstract available

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Figures

Figure 1.
Figure 1.
Relationship among miRNA, TP53 and TERT levels in 13q14del chronic lymphocytic leukemia. (A, B) Relationship between TERT and TP53 levels in: (A) 13q14del CLL, (B) CLL with no chromosomal abnormalities. (C-F) Relationship between percentage of deleted nuclei and levels of (C) miR-15a, (D) miR-16-1, (E) TP53, (F) TERT. (G) Proposed network among miR-15a/miR-16-1, TP53, and TERT expression. Down-regulation of miR-15a/miR-16-1, due to 13q14 deletion, leads to increased TP53 levels which, in turn, down-regulate levels of TERT, the catalytic component of the telomerase complex.
See this image and copyright information in PMC

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