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Review
. 2017 Apr;14(2):265-273.
doi: 10.1007/s13311-017-0526-y.

Medulloblastoma: Molecular Classification-Based Personal Therapeutics

Tenley C Archer  1   2 , Elizabeth L Mahoney  1 , Scott L Pomeroy  3   4
Affiliations
Review

Medulloblastoma: Molecular Classification-Based Personal Therapeutics

Tenley C Archer et al. Neurotherapeutics. 2017 Apr.

Abstract

Recent advances in cancer genomics have revealed 4 distinct subgroups of medulloblastomas, each with unique transcription profiles, DNA alterations and clinical outcome. Molecular classification of medulloblastomas improves predictions of clinical outcome, allowing more accurate matching of intensity of conventional treatments with chemotherapy and radiation to overall prognosis and setting the stage for the introduction of targeted therapies.

Keywords: DNA methylation; Genomic; Group 3; Group 4; MYC; Medulloblastoma; SHH; Subgroups; WHO; WNT.

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References

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