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Editorial
. 2017 Jul;83(7):1365-1368.
doi: 10.1111/bcp.13281. Epub 2017 Apr 6.

When less is more - efficacy with less toxicity at the ED50

Affiliations
Editorial

When less is more - efficacy with less toxicity at the ED50

Simon Dimmitt et al. Br J Clin Pharmacol. 2017 Jul.
No abstract available

Keywords: dose-response; effective dose 50; pharmaceutical marketing.

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Figures

Figure 1
Figure 1
A graphical representation showing relationship of drug dose and effect – toxicity and clinical

References

    1. Peck C, Urquhart J. Postmarketing drug dosage changes of 499 FDA‐approved new molecular entities, 1980‐1999. Pharmacoepidemiol Drug Saf 2002; 11: 439–446. - PubMed
    1. Cross J, Lee H, Westelinck A, Nelson J, Grudzinskas C, Peck C. Postmarketing drug dosage changes of 499 FDA‐approved new molecular entities, 1980‐1999. Pharmacoepidemiol Drug Saf 2002; 11: 439–446. - PubMed
    1. Martin JH, Fay MF. Surrogate end‐points in clinical practice: are we providing worse care? Intern Med J 2010; 40: 395–398. - PubMed
    1. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrback K, et al. Bariatric surgery. A systematic review and meta‐analysis. JAMA 2004; 292: 1724–1737. - PubMed
    1. Vamos M, Erath JW, Hohnloser SH. Digoxin‐associated mortality: a systematic review and meta‐analysis of the literature. Eur Heart J 2015; 36: 1831–1838. - PubMed

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