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. 1988 Jun 30;333(6176):824-9.
doi: 10.1038/333824a0.

DNA sequence determinants of CAP-induced bending and protein binding affinity

M R Gartenberg  1 , D M Crothers
Affiliations

DNA sequence determinants of CAP-induced bending and protein binding affinity

M R Gartenberg et al. Nature. .

Abstract

The sites of DNA bending induced by binding catabolite activator protein are identified and shown to coincide with positions where DNA grooves face the protein. The bendability of DNA with different sequences at these bend centres parallels the bending preference of the sequences in nucleosomal DNA. Anisotropic DNA bendability significantly affects the structure and strength of regulatory protein-DNA complexes.

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