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Review
. 2017 Apr 7;18(4):789.
doi: 10.3390/ijms18040789.

Advances in Skin Regeneration Using Tissue Engineering

Komal Vig  1 , Atul Chaudhari  2 , Shweta Tripathi  3 , Saurabh Dixit  4 , Rajnish Sahu  5 , Shreekumar Pillai  6 , Vida A Dennis  7 , Shree R Singh  8
Affiliations
Review

Advances in Skin Regeneration Using Tissue Engineering

Komal Vig et al. Int J Mol Sci. .

Abstract

Tissue engineered skin substitutes for wound healing have evolved tremendously over the last couple of years. New advances have been made toward developing skin substitutes made up of artificial and natural materials. Engineered skin substitutes are developed from acellular materials or can be synthesized from autologous, allograft, xenogenic, or synthetic sources. Each of these engineered skin substitutes has their advantages and disadvantages. However, to this date, a complete functional skin substitute is not available, and research is continuing to develop a competent full thickness skin substitute product that can vascularize rapidly. There is also a need to redesign the currently available substitutes to make them user friendly, commercially affordable, and viable with longer shelf life. The present review focuses on providing an overview of advances in the field of tissue engineered skin substitute development, the availability of various types, and their application.

Keywords: skin regeneration; skin substitutes; tissue engineering.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Normal skin structure.
Figure 2
Figure 2
Tissue engineered skin substitute preparation. Bold lines indicate cell type for tissue engineered substitute and dotted lines indicate cell source.
Figure 3
Figure 3
Tissue engineered skin substitutes. (a) Acellular: i. Karoderm ii. Biobrane iii. Integra (b) Epidermal Autologous: i. Cell Spray ii. Epicel iii. Laserskin (c) Dermal Autologous: i. Hyalograft 3D (d) Dermal Allogenic: i. TransCyte ii. Dermagraft (e) Dermal Xenogenic: i. Permacol (f) Epidermal/Dermal (Composite) Autologous i. Tissue tech Autograft system (g) Epidermal/Dermal (Composite) Allograft i. Apligraf.
See this image and copyright information in PMC

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