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Case Reports
. 1979 Feb;43(2):718-22.
doi: 10.1002/1097-0142(197902)43:2<718::aid-cncr2820430247>3.0.co;2-r.

Management of asparaginase induced hemorrhagic pancreatitis complicated by pseudocyst

R Greenstein, C Nogeire, T Ohnuma, A Greenstein
Case Reports

Management of asparaginase induced hemorrhagic pancreatitis complicated by pseudocyst

R Greenstein et al. Cancer. 1979 Feb.

Abstract

Asparaginase induced hemorrhagic pancreatitis is a rare but serious development occurring in less than 0.5% of patients treated with this drug. Severe pancreatitis with progressive abdominal distention, toxemia, hypotension and respiratory insufficiency occurred in an 18-year-old patient with acute lymphoblastic leukemia following treatment with asparaginase. There was a dramatic response to high flow peritoneal lavage with rapid recovery within 24 hours from a moribund state. The subsequent development of a pseudocyst, with progressive increase in size and development of obstructive symptoms, required surgical decompression. Transgastric cystogastrostomy was successfully carried out.

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