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Comment
. 2017 Apr 6;169(2):186-187.
doi: 10.1016/j.cell.2017.03.030.

ESCRTing Necroptosis

Hongyan Guo  1 , William J Kaiser  2
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ESCRTing Necroptosis

Hongyan Guo et al. Cell. .
Free article

Abstract

Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.

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