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doi: 10.1016/j.stem.2017.03.018.
TLRgeting Evasion of Immune Pathways in Glioblastoma
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- PMID: 28388423
- DOI: 10.1016/j.stem.2017.03.018
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TLRgeting Evasion of Immune Pathways in Glioblastoma
Cell Stem Cell.
.
Free article
Abstract
Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression.Cell Stem Cell. 2017 Apr 6;20(4):450-461.e4. doi: 10.1016/j.stem.2016.12.001. Epub 2017 Jan 12. Cell Stem Cell. 2017. PMID: 28089910 Free PMC article.
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