[Behavior of contrast media in liver tumors in computerized tomography--correlation between pharmacokinetics and histological structure]

Abstract

The characteristics of contrast medium in liver tumours were studied via CT in a prospective study in 247 patients. In 30 cases, dynamic CT was performed additionally. Analysis of the time density diagrams shows the pharmacokinetics of the lesion corresponding to the histological structure classified into 4 types according to Claussen and Lochner. We were able to prove that at a fast scan (15 slices in 3 minutes) the specific pharmacokinetics of a tumour can be determined. Classification in this way is possible in the majority of cases. Pharmacokinetics of tumours are related to histology, but a specific histological diagnosis cannot be made as yet.