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. 2017 May 15;27(10):2124-2128.
doi: 10.1016/j.bmcl.2017.03.071. Epub 2017 Mar 24.

Calofolic acids A-F, chromanones from the bark of Calophyllum scriblitifolium with vasorelaxation activity

Alfarius Eko Nugroho  1 , Tadahiro Sasaki  1 , Toshio Kaneda  1 , A Hamid A Hadi  2 , Hiroshi Morita  3
Affiliations

Calofolic acids A-F, chromanones from the bark of Calophyllum scriblitifolium with vasorelaxation activity

Alfarius Eko Nugroho et al. Bioorg Med Chem Lett. .

Abstract

Vasorelaxation activity guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of 6 chromanones (calofolic acids A-F, 1-6). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. All isolated chromanones showed dose-dependent vasorelaxation activity on isolated rat aorta.

Keywords: Calofolic acids; Calophyllum scriblitifolium; Chromanones; Vasorelaxation activity.

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