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Multicenter Study
. 2017 Jun 7;12(6):885-892.
doi: 10.2215/CJN.09270816. Epub 2017 Apr 7.

Sleep and CKD in Chinese Adults: A Cross-Sectional Study

Junjuan Li  1 , Zhe Huang  2 , Jinhong Hou  1 , Amy M Sawyer  3 , Zhijun Wu  4 , Jianfang Cai  5   6 , Gary Curhan  7 , Shouling Wu  2 , Xiang Gao  8
Affiliations
Multicenter Study

Sleep and CKD in Chinese Adults: A Cross-Sectional Study

Junjuan Li et al. Clin J Am Soc Nephrol. .

Abstract

Background and objectives: To assess the association between self-reported sleep duration and quality and odds of having CKD in Chinese adults on the basis of a community study.

Design, setting, participants, & measurements: In this cross-sectional study, we included 11,040 Chinese adults who participated in an ongoing prospective study, the Kailuan cohort. Survey questionnaire items addressed insomnia, daytime sleepiness, snoring, and sleep duration during their 2012 interview. Overall sleep quality was evaluated by summarizing these four sleep parameters. Fasting blood samples and single random midstream morning urine samples were collected in 2012 and analyzed for serum creatinine and proteinuria. CKD was defined by eGFR<60 ml/min per 1.73 m2 or proteinuria >300 mg/dl. We also examined those at high or very high risk of having CKD, on the basis of the Kidney Disease Improving Global Outcomes recommendations. The association between sleep quality and CKD was assessed using logistic regression model.

Results: Worse overall sleep quality was associated with higher likelihood of being high or very high risk for CKD (multiadjusted odds ratio, 2.69; 95% confidence interval, 1.30 to 5.59 comparing two extreme categories; P trend <0.01), but not overall CKD (multiadjusted odds ratio, 1.58; 95% confidence interval, 0.89 to 2.80 comparing two extreme categories; P trend =0.46), after adjusting for potential confounders. Specifically, individuals with worse sleep quality were more likely to have proteinuria (multiadjusted odds ratio, 1.95; 95% confidence interval, 1.03 to 3.67 comparing two extreme categories; P trend =0.02), rather than lower eGFR level (multiadjusted mean eGFR levels were 96.4 and 93.6 ml/min per 1.73 m2 in the two extreme sleep categories, respectively; P trend =0.13). However, there was no statistically significant association between individual sleep parameters and CKD status.

Conclusions: Worse overall sleep quality was associated with higher odds of being high or very high risk for CKD and proteinuria in Chinese adults.

Keywords: Adult; Cross-Sectional Studies; Fasting; Humans; Kidney Function Tests; Logistic Models; Prospective Studies; Renal Insufficiency, Chronic; Self Report; Sleep; Sleep Initiation and Maintenance Disorders; Snoring; Surveys and Questionnaires; chronic kidney disease; creatinine; cross-sectional study; glomerular filtration rate; proteinuria.

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