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Review
. 2017 May 16;8(20):33990-34000.
doi: 10.18632/oncotarget.16722.

Association of body mass index with bladder cancer risk: a dose-response meta-analysis of prospective cohort studies

Limin Zhao  1 , Xiaoqin Tian  2 , Xueyan Duan  1 , Yongxiu Ye  1 , Min Sun  3 , Junfang Huang  1
Affiliations
Review

Association of body mass index with bladder cancer risk: a dose-response meta-analysis of prospective cohort studies

Limin Zhao et al. Oncotarget. .

Abstract

Prospective epidemiologic studies on the association between body mass index (BMI) and bladder cancer yielded inconsistent findings. This study sought to quantitatively summarize the evidence by performing a dose-response meta-analysis on prospective cohort studies. Eligible studies were retrieved via PubMed and Embase databases, and by manual review of the references. Linear and nonlinear trend analyses were conducted to explore the relationships between BMI and bladder cancer risk. Meta-analyses on the categories of overweight and obesity were also conducted. The summary relative risk (SRR) was estimated. Heterogeneity across the studies was explored through subgroup analyses based on gender, age, year of publication, sample size, assessment of BMI, geographic location, physical activity and family history of cancer. A total of 14 prospective cohort studies involving 12,642 cases were included. Result of the dose-response analysis showed a nonlinear positive relationship between BMI and bladder cancer (SRR = 1.03, 95% CI: 1.01-1.06, P-nonlinearity =0.031), suggesting that per 5 kg/m2 increment on BMI corresponded to a 3.1 % increase of bladder cancer risk, especially BMI exceed 30kg/m2.Furthermore, significant positive association was also observed between obesity category and bladder cancer risk (SRR: 1.10, 95%CI: 1.03-1.17). In summary, this dose-response meta-analysis suggests a nonlinear positive association between BMI and bladder cancer risk. Further studies are required to confirm these findings and elucidate the pathogenic mechanisms.

Keywords: bladder cancer; body mass index; dose-response; meta-analysis; risk.

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Conflict of interest statement

CONFLICTS OF INTEREST

We declare that we have no conflicts of interest.

Figures

Figure 1
Figure 1. Flow chart of the study selection
Figure 2
Figure 2. The nonlinear dose-response meta-analysis of body mass index (BMI) and risk of bladder cancer
Figure 3
Figure 3. Meta-analysis of studies that examined the association between overweight category and bladder cancer risk
Figure 4
Figure 4. Meta-analysis of studies that examined the association between obesity category and bladder cancer risk
See this image and copyright information in PMC

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